Daniel Winston Bellott
Research Scientist
CV | Email | LinkedIn | ResearchGate | GitHub
Experience:
Whitehead Institute (2010-present)
Research Scientist
Education:
Massachusetts Institute of Technology (2003-2010)
PhD, Biology
Thesis: Sequencing the Chicken Sex Chromosomes
Advisor: David C. Page
Boston University (1999-2003)
BA, Biochemistry and Molecular Biology, Ancient Greek and Latin
Work For Distinction: Localization of human and mouse Xist RNA in Xenopus oocytes
Advisor: James O. Deshler
Boston University Academy (1996-1999)
Senior Thesis: Estimating the de novo human mutation rate from sporadic genetic disease
Advisor: Dean Tolan
Publications:
Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians
Kathleen W Higgins, Akihiro Itoigawa, Yasuka Toda, Daniel W Bellott, Rachel Anderson, Roberto Márquez, Jing-Ke Weng
PLoS genetics 21, e1011533 (2025)
Post-transcriptional cross-and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y
Shruthi Rengarajan, Jason Derks, Daniel W Bellott, Nikolai Slavov, David C Page
Genome Research 35, 20-30 (2025)
Where is the boundary of the human pseudoautosomal region?
Daniel W Bellott, Jennifer F Hughes, Helen Skaletsky, Erik C Owen, David C Page
The American Journal of Human Genetics 111, 2530-2541 (2024)
The human Y and inactive X chromosomes similarly modulate autosomal gene expression
Adrianna K San Roman, Helen Skaletsky, Alexander K Godfrey, Neha V Bokil, Levi Teitz, Isani Singh, Laura V Blanton, Daniel W Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C Lasutschinkow, Colleen Keen, Shanlee M Davis, Angela E Lin, Nicole R Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C Page
Cell Genomics 4, 100462-100477 (2024)
The human inactive X chromosome modulates expression of the active X chromosome
Adrianna K San Roman, Alexander K Godfrey, Helen Skaletsky, Daniel W Bellott, Abigail F Groff, Hannah L Harris, Laura V Blanton, Jennifer F Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C Lasutschinkow, Colleen Keen, Shanlee M Davis, Nicole R Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C Page
Cell Genomics 3, 100259 (2023)
SHIMS 3.0: Highly efficient single-haplotype iterative mapping and sequencing using ultra-long nanopore reads
Daniel W Bellott, Ting-Jan Cho, Emily K Jackson, Helen Skaletsky, Jennifer F Hughes, David C Page
PLoS One 17, e0269692 (2022)
A gene deriving from the ancestral sex chromosomes was lost from the X and retained on the Y chromosome in eutherian mammals
Jennifer F Hughes, Helen Skaletsky, Peter K Nicholls, Alexis Drake, Tatyana Pyntikova, Ting-Jan Cho, Daniel W Bellott, David C Page
BMC Biology 20, 133 (2022)
GC-biased gene conversion in X-Chromosome palindromes conserved in human, chimpanzee, and rhesus macaque
Emily K Jackson, Daniel W Bellott, Helen Skaletsky, David C Page
G3: Genes, Genomes, Genetics 11, jkab224 (2021)
Large palindromes on the primate X Chromosome are preserved by natural selection
Emily K Jackson, Daniel W Bellott, Ting-Jan Cho, Helen Skaletsky, Jennifer F Hughes, Tatyana Pyntikova, David C Page
Genome Research 31, 1352-1337 (2021)
Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals
Daniel W Bellott, David C Page
Genome Research 31, 210-198 (2021)
Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages
Jennifer F Hughes, Helen Skaletsky, Tatyana Pyntikova, Natalia Koutseva, Terje Raudsepp, Laura G Brown, Daniel W Bellott, Ting-Jan Cho, Shannon Dugan-Rocha, Ziad Khan, Colin Kremitzki, Catrina Fronick, Tina A Graves-Lindsay, Lucinda Fulton, Wesley C Warren, Richard K Wilson, Elaine Owens, James E Womack, William J Murphy, Donna M Muzny, Kim C Worley, Bhanu P Chowdhary, Richard A Gibbs, David C Page
Genome Research 30, 1726-1716 (2020)
Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing
Peter K Nicholls, Daniel W Bellott, Ting-jan Cho, Tatyana Pyntikova, David C Page
G3: Genes, Genomes, Genetics 9, 1486-1481 (2019)
Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes
Jan E Janečka, Brian W Davis, Sharmila Ghosh, Nandina Paria, Pranab J Das, Ludovic Orlando, Mikkel Schubert, Martin K Nielsen, Tom A E Stout, Wesley Brashear, Gang Li, Charles D Johnson, Richard P Metz, Al Muatasim Al Zadjali, Charles C Love, Dickson D Varner, Daniel W Bellott, William J Murphy, Bhanu P Chowdhary, Terje Raudsepp
Nature Communications 9, 2945 (2018)
Cost-effective, high-throughput, single-haplotype iterative mapping and sequencing for complex genomic structures
Daniel W Bellott, Ting-Jan Cho, Jennifer F Hughes, Helen Skaletsky, David C Page
Nature Protocols 13, 787-809 (2018)
Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution
Sahin Naqvi, Daniel W Bellott, Kathy S Lin, David C Page
Genome Research 28, 474-483 (2018)
Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators
Daniel W Bellott, Helen Skaletsky, Ting-Jan Cho, Laura Brown, Devin Locke, Nancy Chen, Svetlana Galkina, Tatyana Pyntikova, Natalia Koutseva, Tina Graves, Colin Kremitzki, Wesley C Warren, Andrew G Clark, Elena Gaginskaya, Richard K Wilson, David C Page
Nature Genetics 49, 387-394 (2017)
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes
Michelle A Carmell, Gregoriy A Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C van Wolfswinkel, Kyomi J Igarashi, Daniel W Bellott, Michael Nefedov, Peter W Reddien, George C Enders, Vladimir N Uversky, Craig C Mello, David C Page
eLife 5, e19993 (2016)
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
Daniel W Bellott, Jennifer F Hughes, Helen Skaletsky, Laura G Brown, Tatyana Pyntikova, Ting-Jan Cho, Natalia Koutseva, Sara Zaghlul, Tina Graves, Susie Rock, Colin Kremitzki, Robert S Fulton, Shannon Dugan, Yan Ding, Donna Morton, Ziad Khan, Lora Lewis, Christian Buhay, Qiaoyan Wang, Jennifer Watt, Michael Holder, Sandy Lee, Lynne Nazareth, Jessica Alföldi, Steve Rozen, Donna M Muzny, Wesley C Warren, Richard A Gibbs, Richard K Wilson, David C Page
Nature 508, 494-499 (2014)
No bull: Upholding community standards in public sharing of biological datasets
Jennifer F Hughes, Helen Skaletsky, Daniel W Bellott, Bhanu P Chowdhary, Wesley C Warren, Kim C Worley, Richard K Wilson, Richard A Gibbs, David C Page
Proceedings of the National Academy of Sciences of the United States of America 110, E4277 (2013)
Identification of avian W-linked contigs by short-read sequencing
Nancy Chen, Daniel W Bellott, David C Page, Andrew G Clark
BMC Genomics 13, 183 (2012)
Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition
Daniel W Bellott, Helen Skaletsky, Tatyana Pyntikova, Elaine R Mardis, Tina Graves, Colin Kremitzki, Laura G Brown, Steve Rozen, Wesley C Warren, Richard K Wilson, David C Page
Nature 466, 612-616 (2010)
Reconstructing the evolution of vertebrate sex chromosomes
Daniel W Bellott, David C Page
Cold Spring Harbor Symposia on Quantitative Biology 74, 345-353 (2009)
Preprints:
Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y
Shruthi Rengarajan, Jason Derks, Daniel W Bellott, Nikolai Slavov, David C Page
bioRxiv (2024)
Where is the boundary of the human pseudoautosomal region?
Daniel W Bellott, Jennifer F Hughes, Helen Skaletsky, Erik C Owen, David C Page
bioRxiv (2024)
The human Y and inactive X chromosomes similarly modulate autosomal gene expression
Adrianna K San Roman, Helen Skaletsky, Alexander K Godfrey, Neha V Bokil, Levi Teitz, Isani Singh, Laura V Blanton, Daniel W Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C Lasutschinkow, Colleen Keen, Shanlee M Davis, Angela E Lin, Nicole R Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C Page
bioRxiv (2023)
A gene-by-gene mosaic of dosage compensation strategies on the human X chromosome
Adrianna K San Roman, Alexander K Godfrey, Helen Skaletsky, Daniel W Bellott, Abigail F Groff, Laura V Blanton, Jennifer F Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C Lasutschinkow, Colleen Keen, Shanlee M Davis, Nicole R Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C Page
bioRxiv (2021)
GC-biased gene conversion in X-Chromosome palindromes conserved in human, chimpanzee, and rhesus macaque
Emily K Jackson, Daniel W Bellott, Helen Skaletsky, David C Page
bioRxiv (2021)
Large palindromes on the primate X Chromosome are preserved by natural selection
Emily K Jackson, Daniel W Bellott, Ting-Jan Cho, Helen Skaletsky, Jennifer F Hughes, Tatyana Pyntikova, David C Page
bioRxiv (2020)
SHIMS 3.0: Highly efficient single-haplotype iterative mapping and sequencing using ultra-long nanopore reads
Daniel W Bellott, Ting-Jan Cho, Emily K Jackson, Helen Skaletsky, Jennifer F Hughes, David C Page
bioRxiv (2020)
Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals
Daniel W Bellott, David C Page
bioRxiv (2020)
Locating a transgene integration site by nanopore sequencing
Peter K Nicholls, Daniel W Bellott, Ting-jan Cho, Tatyana Pyntikova, David C. Page
bioRxiv (2019)
Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution
Sahin Naqvi, Daniel W Bellott, Kathy S Lin, David C Page
bioRxiv (2017)
Cost-effective, high-throughput, single-haplotype iterative mapping and sequencing for complex genomic structures
Daniel W Bellott, Ting-Jan Cho, Jennifer F Hughes, Helen Skaletsky, David C Page
bioRxiv (2017)
Presentations:
Dosage-sensitive regulators are preferentially retained on vertebrate Y and W chromosomes
Talk
23rd International Colloquium on Animal Cytogenetics and Genomics (June 2018)
Comparative Cytogenetics 12, 299-360 (2018)
Producing finished quality sequence of structurally complex genomic regions with SHIMS 2.0
Talk
NHGRI Advanced DNA Sequencing Technology Development Open Meeting (May 2017)
Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators
Talk
AGA 2015 - Chromosome Evolution: Molecular Mechanisms & Evolutionary Consequences (Aug 2015)
A billion years of sex chromosome evolution
Talk
CSHL The Biology of Genomes (May 2012)
Convergent evolution of avian and mammalian sex chromosomes
Poster
Cold Spring Harbor Symposia on Quantitative Biology - Evolution: The Molecular Landscape (May 2009)
Convergent evolution of the human and chicken sex chromosomes
Poster
HHMI Science Meeting (Nov 2008)
Convergent evolution of the human and chicken sex chromosomes
Poster
CSHL The Biology of Genomes (May 2008)