Alignment of vertebrate GCNA proteins.

Vertebrate GCNA proteins show little conservation of primary amino acid sequence outside of structured domains. SUMO-interacting motifs (SIMs) (yellow) comprise small islands of conservation within the IDRs (green). Structured regions are color coded as follows: zinc metalloprotease (blue), zinc finger (purple), and HMG box (red). Residues identical in 70% of the sequences are shaded black; similar residues are gray.